Journal article
Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01–positive vancomycin-induced DRESS sharing an HLA class II haplotype
N Nakkam, A Gibson, E Mouhtouris, KC Konvinse, NE Holmes, KY Chua, P Deshpande, D Li, DA Ostrov, J Trubiano, EJ Phillips
Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2021
Abstract
All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to dalbavancin however two showed cross-reactivity to teicoplanin and telavancin. Adjunctive diagnostic testing should be considered to detect potential cross-reactivity amongst glycopeptides.
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
E.J.P. receives funding from the National Institutes of Health (grants 1P50GM11530501, R21AI139021, R34AI136815, and 1 R01 HG010863-01) and the National Health and Medical Research Council of Australia). J.A.T. is supported by a National Health and Medical Research Council postgraduate scholarship (GNT 1139902) and postgraduate scholarship from the National Centre for Infections in Cancer. K.C.K. is supported by the National Institutes of Health (grants F30AI131780 and T32GM7347).